1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion

Base Information

Chemical Name:1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion
CAS No.:1239685-46-1
Molecular Formula:C₂₁H₂₀ClFN₄O₅
Molecular Weight:462.865
Hs Code.:

Synonyms:1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion

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Chemical Property of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion

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Technology Process of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion

There total 5 articles about 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1239685-45-0
1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(methoxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion

: 1239685-46-1
1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion

Guidance literature:: 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(methoxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h; Cooling with ice;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=<= 2;

Reference yield:

: 1239691-18-9
1-(4-chlorobenzyl)-3-(methoxycarbonylmethyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dion

: 1239685-46-1
1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / tert-butyl alcohol / 32 h / Reflux

2.1: lithium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C / Cooling with ice

2.2: pH < 2

With acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; tert-butyl alcohol;

Reference yield:

: 1239685-39-2
1-(4-chlorobenzyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dione

: 1239685-46-1
1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.08 h / 20 °C

1.2: 3 h / 20 °C

2.1: acetic acid / tert-butyl alcohol / 32 h / Reflux

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C / Cooling with ice

3.2: pH <= 2

With water; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hydroxide; In tetrahydrofuran; methanol; tert-butyl alcohol;