(E)-N-benzyl-3-(4-fluorophenyl)-2-nitroacrylamide

Base Information

Chemical Name:(E)-N-benzyl-3-(4-fluorophenyl)-2-nitroacrylamide
CAS No.:868240-44-2
Molecular Formula:C₁₆H₁₃FN₂O₃
Molecular Weight:300.289
Hs Code.:

Synonyms:(E)-N-benzyl-3-(4-fluorophenyl)-2-nitroacrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-benzyl-3-(4-fluorophenyl)-2-nitroacrylamide

Chemical Property:

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Technology Process of (E)-N-benzyl-3-(4-fluorophenyl)-2-nitroacrylamide

There total 2 articles about (E)-N-benzyl-3-(4-fluorophenyl)-2-nitroacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 129222-48-6
N-benzyl-2-nitroacetamide

: 459-57-4
4-fluorobenzaldehyde

: 868240-44-2
(E)-N-benzyl-3-(4-fluorophenyl)-2-nitroacrylamide

Guidance literature:: With 4-methyl-morpholine; titanium tetrachloride; In tetrahydrofuran; dichloromethane; at -10 - 20 ℃;
DOI:10.1021/jo051334f

Reference yield:

: 100-46-9
benzylamine

: 868240-44-2
(E)-N-benzyl-3-(4-fluorophenyl)-2-nitroacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / methanol / 72 h / 20 °C

2: 49 percent / TiCl₄; N-methylmorpholine / tetrahydrofuran; CH₂Cl₂ / -10 - 20 °C

With 4-methyl-morpholine; titanium tetrachloride; In tetrahydrofuran; methanol; dichloromethane; 2: Knoevenagel condensation;
DOI:10.1021/jo051334f

Reference yield:

: 868240-44-2
(E)-N-benzyl-3-(4-fluorophenyl)-2-nitroacrylamide

: 75-30-9
2-iodo-propane

: N-benzyl-3-(4-fluorophenyl)-2-nitropropionamide

: 666705-51-7
N-benzyl-3-(4-fluorophenyl)-4-methyl-2-nitropentanamide

Guidance literature:: With triethyl borane; tri-n-butyl-tin hydride; zinc trifluoromethanesulfonate; oxygen; In diethyl ether; hexane; dichloromethane; at -78 ℃; for 4h;
DOI:10.1021/jo051334f