6-Chloro-3-nitroimidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 6-Chloro-3-nitroimidazo[1,2-b]pyridazine
• CAS No.: 18087-76-8
• Molecular Formula: C6H3ClN4O2
• Molecular Weight: 198.568
• Hs Code.: 2933990090
• European Community (EC) Number: 628-850-3
• DSSTox Substance ID: DTXSID60441394
• Wikidata: Q72455843
• Mol file: 18087-76-8.mol

Synonyms:6-Chloro-3-nitroimidazo[1,2-b]pyridazine;18087-76-8;6-Chloro-3-nitro-imidazo[1,2-b]pyridazine;6-CHLORO-3-NITRO-IMIDAZO[1,2-B]PYRIDAZIN;Imidazo[1,2-b]pyridazine, 6-chloro-3-nitro-;MFCD08276991;SCHEMBL430605;DTXSID60441394;IJEZMDPWGDWYKJ-UHFFFAOYSA-N;AKOS005256494;AC-3222;CS-W003502;PB29519;DS-10707;SY004902;6-chloro-3-nitro imidazo[1,2-b]pyridazine;6-chloro-3-nitroimidazo-[1,2-b]pyridazine;AM20090065;FT-0685159;EN300-117366;A881055;W-206289;6-Chloro-3-nitro-imidazo[1,2-b]pyridazine, >=98.0%;Z1255458268

Chemical Property of 6-Chloro-3-nitroimidazo[1,2-b]pyridazine

Chemical Property:

• Melting Point: 142-145 °C
• Refractive Index: 1.792
• PSA: 76.01000
• Density: 1.856 g/cm³
• LogP: 1.81410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 197.9944530
• Heavy Atom Count: 13
• Complexity: 221

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-3-nitroimidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NN2C1=NC=C2[N+](=O)[O-])Cl

Technology Process of 6-Chloro-3-nitroimidazo[1,2-b]pyridazine

There total 2 articles about 6-Chloro-3-nitroimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-chloroimidazo[1,2-b]pyridazine (6775-78-6) → 6-chloro-3-nitroimidazo<1,2-b>pyridazine (18087-76-8)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 20 ℃; for 5h;

Reference yield:

→ 6-chloro-3-nitroimidazo<1,2-b>pyridazine (18087-76-8)

Guidance literature:

6-Chlor-imidazo<1,2-b>pyridazin, HNO3/H2SO4;

DOI:10.1016/0040-4020(68)89024-6

Reference yield: 83.0%

(3,4-dichlorobenzyl)(methyl)amine (5635-67-6) + 6-chloro-3-nitroimidazo<1,2-b>pyridazine (18087-76-8) → (3,4-dichloro-benzyl)-methyl-(3-nitro-imidazo[1,2-b]pyridazin-6-yl)-amine (1150567-88-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 160 ℃; for 8h; Microwave irradiation;

upstream raw materials:

6-chloroimidazo[1,2-b]pyridazine

Downstream raw materials:

3-amino-6-chloroimidazo[1,2-b]pyridazine

6-amino-3-nitroimidazo[1,2-b]pyridazine

3,6-diaminoimidazo[1,2-b]pyridazine

6-amino-3-bis(phenoxycarbomyl)aminoimidazo[1,2-b]pyridazine

Refernces

• 1、 -. "Synthesis method of 3-nitro-6- chloroimidazo[1,2-b] pyridazine". Paragraph 0013; 0015; 0017; 0018; 0019; 0020. . Retrieved 2017/08/29.
• 2、 -. "SUBSTITUTED IMIDAZO[1,2B]PYRIDAZINE COMPOUNDS AS TRK KINASE INHIBITORS". Page/Page column 35. . Retrieved 2010/04/25.