(S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate

Base Information

Chemical Name:(S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate
CAS No.:135697-38-0
Molecular Formula:C₄₀H₅₅N₅O₇
Molecular Weight:717.906
Hs Code.:

(S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate

Synonyms:(S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate

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Chemical Property of (S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate

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Technology Process of (S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate

There total 14 articles about (S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 135697-37-9
{(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester

: 1710-98-1
p-tert-butyl benzoyl chloride

: 135697-38-0
(S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate

Guidance literature:: With dmap; In dichloromethane;
DOI:10.1021/jo00021a010

Reference yield:

: 128726-47-6
(+)-(S)-6-hydroxymethyl-2-piperidinone

: 135697-38-0
(S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: 70.4 percent / N-methylimidazole / CH₂Cl₂ / 24 h / 0 °C

2: 60 percent / DMAP, Et₃N / CH₂Cl₂ / 8 h / Ambient temperature

3: 43 percent / potassium tert-butoxide / dimethylsulfoxide

4: pyridine / 8 h / Ambient temperature

5: 1 M LiOH / tetrahydrofuran; 2-methyl-propan-2-ol; ethanol; H₂O / 0.08 h

6: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide methiodide, 4-(dimethylamino)pyridine / CH₂Cl₂

7: 82 percent / CH₂Cl₂ / 8 h / Ambient temperature

8: 84 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

With pyridine; 1-methyl-1H-imidazole; dmap; lithium hydroxide; potassium tert-butylate; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jo00021a010

Reference yield:

: 135697-06-2
(S)-(6-oxo-2-piperidinyl)methyl 4-methylbenzenesulfonate

: 135697-38-0
(S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / DMAP, Et₃N / CH₂Cl₂ / 8 h / Ambient temperature

2: 43 percent / potassium tert-butoxide / dimethylsulfoxide

3: pyridine / 8 h / Ambient temperature

4: 1 M LiOH / tetrahydrofuran; 2-methyl-propan-2-ol; ethanol; H₂O / 0.08 h

5: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide methiodide, 4-(dimethylamino)pyridine / CH₂Cl₂

6: 82 percent / CH₂Cl₂ / 8 h / Ambient temperature

7: 84 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

With pyridine; dmap; lithium hydroxide; potassium tert-butylate; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jo00021a010