1,3-Dihydro-2h-imidazo[4,5-b]pyrazin-2-one

Base Information

• Chemical Name: 1,3-Dihydro-2h-imidazo[4,5-b]pyrazin-2-one
• CAS No.: 16328-63-5
• Molecular Formula: C5H4N4O
• Molecular Weight: 136.11146
• Hs Code.: 2933990090
• NSC Number: 193442,129582,217339
• DSSTox Substance ID: DTXSID60299352
• Wikidata: Q82041703
• Mol file: 16328-63-5.mol

Synonyms:16328-63-5;1,3-dihydro-2h-imidazo[4,5-b]pyrazin-2-one;1H-Imidazo[4,5-b]pyrazin-2(3H)-one;1,3-dihydroimidazo[4,5-b]pyrazin-2-one;2H-Imidazo[4,5-b]pyrazin-2-one;NSC217339;dihydro-imidazolopyrazinone;2H-Imidazo[4,5-b]pyrazin-2-one,1,3-dihydro-;SCHEMBL340668;DTXSID60299352;1h-imidazo[4,5-b]pyrazin-2-ol;AMY37688;MFCD08669462;NSC129582;NSC193442;AKOS006291750;NSC-129582;NSC-193442;NSC-217339;AC-30781;BS-15580;CS-0149718;FT-0720735;D83988;Z1198180620

Chemical Property of 1,3-Dihydro-2h-imidazo[4,5-b]pyrazin-2-one

Chemical Property:

• Vapor Pressure: 3.33mmHg at 25°C
• Refractive Index: 1.604
• Boiling Point: 153.4 °C at 760 mmHg
• Flash Point: 46.6 °C
• PSA: 74.43000
• Density: 1.455 g/cm³
• LogP: -0.35380
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 136.03851076
• Heavy Atom Count: 10
• Complexity: 144

Purity/Quality:

97% ^*data from raw suppliers

1H-Imidazo[4,5-b]pyrazin-2(3H)-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C2C(=N1)NC(=O)N2

Technology Process of 1,3-Dihydro-2h-imidazo[4,5-b]pyrazin-2-one

There total 5 articles about 1,3-Dihydro-2h-imidazo[4,5-b]pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

pyrazine-2,3-diamine (13134-31-1) + 1,1'-carbonyldiimidazole (530-62-1) → 1H-imidazo<4,5-b>pyrazin-2(3H)-one (16328-63-5)

Guidance literature:

In tetrahydrofuran; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.cclet.2015.08.015

Reference yield: 57.0%

pyrazine-2,3-diamine (13134-31-1) + urea (57-13-6) → 1H-Imidazo<4,5-b>pyrazin-2-ol (16328-63-5)

Guidance literature:

In diphenylether; at 240 ℃; for 5h;

Reference yield: 45.0%

2,3-pyrazinedicarboxylic anhydride (4744-50-7) → 1H-imidazo<4,5-b>pyrazin-2(3H)-one (16328-63-5)

Guidance literature:

With trimethylsilylazide; In tetrahydrofuran; for 30h; Reflux;

DOI:10.1016/j.mencom.2016.01.027

upstream raw materials:

pyrazine-2,3-diamine

urea

1,1'-carbonyldiimidazole

2,3-pyrazinedicarboxylic anhydride

Downstream raw materials:

2-methoxy-1-methyl-1H-imidazo<4,5-b>pyrazine

2-methoxy-4-methyl-4H-imidazo<4,5-b>pyrazine

1,4-dimethyl-1H-imidazo<4,5-b>pyrazin-2(4H)-one

1,3-dimethyl-1H-imidazo<4,5-b>pyrazin-2(3H)-one