5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine 3'-(methyl)N,N-diisopropylphosphoramidite

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine 3'-(methyl)N,N-diisopropylphosphoramidite
CAS No.:111462-77-2
Molecular Formula:C₅₄H₆₄ClN₅O₁₅P₂
Molecular Weight:1120.53
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine 3'-(methyl)N,N-diisopropylphosphoramidite

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine 3'-(methyl)N,N-diisopropylphosphoramidite

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine 3'-(methyl)N,N-diisopropylphosphoramidite

There total 2 articles about 5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine 3'-(methyl)N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 86030-43-5
N,N-diisopropylmethylphosphonamidic chloride

: 80614-95-5
5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine

: 111462-77-2
5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine 3'-(methyl)N,N-diisopropylphosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.35.833

Reference yield:

: 81196-20-5
2-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate

: 111462-77-2
5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5')-(o-chlorophenyl)-thymidine 3'-(methyl)N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / MSNT / pyridine / 1 h / Ambient temperature

2: 85 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / Ambient temperature

With MSNT; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1248/cpb.35.833