(E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal

Base Information

• Chemical Name: (E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal
• CAS No.: 73542-01-5
• Molecular Formula: C₃₂H₄₈ClNO₆S₂
• Molecular Weight: 642.321
• Mol file: 73542-01-5.mol

Synonyms:(E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal

Chemical Property of (E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal

There total 5 articles about (E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3S,4S)-5-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-4-(2-methoxy-ethoxymethoxy)-3-methyl-pentane-1,2-diol → (E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal (73542-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Pb(OAc)4, AcOK / acetonitrile / -25 °C

2: 2.) pyridinium chloride / 1.) -110 deg C, 5 min, -78 deg C, 10 min, 2.) CH₂Cl₂, 20 deg C, 2 h

With lead(IV) acetate; potassium acetate; pyridine hydrochloride; In acetonitrile;

DOI:10.1021/ja00524a046

Reference yield:

[2-Chloro-5-((2E,4E)-(R)-6-{2-[(2S,3R)-3-(S)-1,4-dioxa-spiro[4.4]non-2-yl-2-(2-methoxy-ethoxymethoxy)-butyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-3-methoxy-phenyl]-methyl-amine → (E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal (73542-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / 0.3 M HClO₄ / acetonitrile; H₂O / 40 h / 0 °C

2: 95 percent / Pb(OAc)4, AcOK / acetonitrile / -25 °C

3: 2.) pyridinium chloride / 1.) -110 deg C, 5 min, -78 deg C, 10 min, 2.) CH₂Cl₂, 20 deg C, 2 h

With lead(IV) acetate; perchloric acid; potassium acetate; pyridine hydrochloride; In water; acetonitrile;

DOI:10.1021/ja00524a046

Reference yield:

[2-Chloro-5-((2E,4E)-(R)-6-{2-[(2S,3R)-3-(S)-1,4-dioxa-spiro[4.4]non-2-yl-2-(2-methoxy-ethoxymethoxy)-butyl]-[1,3]dithian-2-yl}-6-hydroxy-2-methyl-hexa-2,4-dienyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester (73547-16-7,73609-93-5) → (E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal (73542-01-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 91 percent / NaH / tetrahydrofuran / 0.25 h / 20 °C

2: 1.) lithium thiomethoxide, 2.) CH₃I, K₂CO₃ / 1.) DMF, 0 deg C, 40 h, 2.) acetone, 23 deg C

3: 87 percent / 0.3 M HClO₄ / acetonitrile; H₂O / 40 h / 0 °C

4: 95 percent / Pb(OAc)4, AcOK / acetonitrile / -25 °C

5: 2.) pyridinium chloride / 1.) -110 deg C, 5 min, -78 deg C, 10 min, 2.) CH₂Cl₂, 20 deg C, 2 h

With lead(IV) acetate; perchloric acid; potassium acetate; pyridine hydrochloride; sodium hydride; lithium methanethiolate; potassium carbonate; methyl iodide; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/ja00524a046

upstream raw materials:

[2-Chloro-5-((2E,4E)-(R)-6-{2-[(2S,3R)-3-(S)-1,4-dioxa-spiro[4.4]non-2-yl-2-(2-methoxy-ethoxymethoxy)-butyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester

[2-Chloro-5-((2E,4E)-(R)-6-{2-[(2S,3R)-3-(S)-1,4-dioxa-spiro[4.4]non-2-yl-2-(2-methoxy-ethoxymethoxy)-butyl]-[1,3]dithian-2-yl}-6-hydroxy-2-methyl-hexa-2,4-dienyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester

Downstream raw materials:

(2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid

(2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid methyl ester