Technology Process of (R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid
There total 11 articles about (R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 94 percent / H2SO4 / Heating
2: 96 percent / K2CO3 / 4 h / 55 °C
3: 90 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C
4: 63 percent / DIBALH / CH2Cl2 / 0 °C / to room temperature
5: 3A molecular sieves / PPL / 24 h / 0 °C
6: p-TSA / CH2Cl2 / Ambient temperature
7: KOH / methanol / Ambient temperature
8: 98 percent / NaH / dimethylformamide / Ambient temperature
9: 93 percent / p-TSA / methanol / Ambient temperature
10: 90 percent / Jones reagent / acetone / 0 °C
With
potassium hydroxide; jones reagent; 3 A molecular sieve; sulfuric acid; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide;
PPL;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(00)61382-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 3A molecular sieves / PPL / 24 h / 0 °C
2: p-TSA / CH2Cl2 / Ambient temperature
3: KOH / methanol / Ambient temperature
4: 98 percent / NaH / dimethylformamide / Ambient temperature
5: 93 percent / p-TSA / methanol / Ambient temperature
6: 90 percent / Jones reagent / acetone / 0 °C
With
potassium hydroxide; jones reagent; 3 A molecular sieve; sodium hydride; toluene-4-sulfonic acid;
PPL;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(00)61382-5
