(R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid

Base Information

Chemical Name:(R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid
CAS No.:155499-22-2
Molecular Formula:C₁₉H₂₀O₄
Molecular Weight:312.365
Hs Code.:

Synonyms:(R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid

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Chemical Property of (R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid

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Technology Process of (R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid

There total 11 articles about (R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 155499-20-0
(S)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propan-1-ol

: 155499-22-2
(R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid

Guidance literature:: With jones reagent; In acetone; at 0 ℃;
DOI:10.1016/S0040-4039(00)61382-5

Reference yield:

: 621-37-4
m-hydroxyphenylacetic acid

: 155499-22-2
(R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 94 percent / H₂SO₄ / Heating

2: 96 percent / K₂CO₃ / 4 h / 55 °C

3: 90 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

4: 63 percent / DIBALH / CH₂Cl₂ / 0 °C / to room temperature

5: 3A molecular sieves / PPL / 24 h / 0 °C

6: p-TSA / CH₂Cl₂ / Ambient temperature

7: KOH / methanol / Ambient temperature

8: 98 percent / NaH / dimethylformamide / Ambient temperature

9: 93 percent / p-TSA / methanol / Ambient temperature

10: 90 percent / Jones reagent / acetone / 0 °C

With potassium hydroxide; jones reagent; 3 A molecular sieve; sulfuric acid; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; PPL; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(00)61382-5

Reference yield:

: 155440-94-1
2-(3-allyloxy)phenyl-1,3-propanediol

: 155499-22-2
(R)-2-(3-Allyloxy-phenyl)-3-benzyloxy-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 3A molecular sieves / PPL / 24 h / 0 °C

2: p-TSA / CH₂Cl₂ / Ambient temperature

3: KOH / methanol / Ambient temperature

4: 98 percent / NaH / dimethylformamide / Ambient temperature

5: 93 percent / p-TSA / methanol / Ambient temperature

6: 90 percent / Jones reagent / acetone / 0 °C

With potassium hydroxide; jones reagent; 3 A molecular sieve; sodium hydride; toluene-4-sulfonic acid; PPL; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(00)61382-5