3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine

Base Information

Chemical Name:3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine
CAS No.:133023-98-0
Molecular Formula:C₃₀H₄₆N₂O₈Si₂
Molecular Weight:618.875
Hs Code.:

Synonyms:3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine

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Technology Process of 3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine

There total 1 articles about 3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 131132-30-4
N³-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyl disiloxane-1,3-diyl)5-methyluridine

: 74-88-4
methyl iodide

: 133023-98-0
3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine

Guidance literature:: With silver(l) oxide; In toluene; for 144h;
DOI:10.1080/15257770008032997

Reference yield:

: 133023-98-0
3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine

: 55486-09-4
2'-O-Methyl-5-methyluridine

Guidance literature:: Multi-step reaction with 2 steps

1: NaOMe / methanol / 96 h

2: 220 mg / NH₄F / methanol / 48 h / Heating

With ammonium fluoride; sodium methylate; In methanol; 1: Elimination / 2: Ring cleavage;
DOI:10.1080/15257770008032997

Reference yield:

: 133023-98-0
3-N-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-5-methyluridine

: 2'-O-(tert-butyldimethylsilyl)-3'-(N-carbonylmethyl)-3'-deoxy-5'-O-(dimethoxytrityl)-5-methyluridinyl-(3'-5')-5'-amino-5'-deoxy-2'-O-methyl-5-methyluridine

Guidance literature:: Multi-step reaction with 6 steps

1: NaOMe / methanol / 96 h

2: 220 mg / NH₄F / methanol / 48 h / Heating

3: 57 percent / SOCl₂ / hexamethylphosphoric acid triamide

4: 66 percent / NaN₃ / dimethylformamide / 2 h / 90 - 100 °C

5: H₂ / Pd/C / ethanol

6: 74 percent / ethanol / 96 h

With ammonium fluoride; thionyl chloride; sodium azide; hydrogen; sodium methylate; palladium on activated charcoal; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; N,N-dimethyl-formamide; 1: Elimination / 2: Ring cleavage / 3: Substitution / 4: Substitution / 5: Catalytic hydrogenation / 6: Substitution;
DOI:10.1080/15257770008032997