N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

• Chemical Name: N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• CAS No.: 1079396-32-9
• Molecular Formula: C₁₇H₁₉FN₆O₂S
• Molecular Weight: 390.441

Synonyms:N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Chemical Property of N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Technology Process of N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 1 articles about N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzyl 4-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate (1079396-09-0) → N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1079396-32-9)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethanol; for 18h; under 760.051 Torr;

Reference yield: 48.0%

N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1079396-32-9) + 2-bromopyrimidine (4595-60-2) → N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(1-(pyrimidin-2-yl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1079396-11-4)

Guidance literature:

With sodium t-butanolate; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Sealed vial;

Reference yield: 45.0%

N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1079396-32-9) + isopropyl chloroformate (108-23-6) → 4-[4-(2-fluoro-4-methanesulfonyl-phenylamino)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid isopropyl ester (1079396-10-3)

Guidance literature:

With triethylamine; In dichloromethane; toluene; at 20 ℃; for 1h;

upstream raw materials:

benzyl 4-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

Downstream raw materials:

1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-N-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-amine

N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

4-[4-(2-fluoro-4-methanesulfonyl-phenylamino)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid isopropyl ester

N-(2-fluoro-4-(methylsulfonyl)phenyl)-1-(1-(pyrimidin-2-yl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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