tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate

Base Information

• Chemical Name: tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate
• CAS No.: 872530-81-9
• Molecular Formula: C₂₆H₂₉N₃O₂S₂
• Molecular Weight: 479.667

Synonyms:tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate

Chemical Property of tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate

Chemical Property:

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Technology Process of tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate

There total 4 articles about tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (872530-68-2) + phenyl isothiocyanate (103-72-0) → tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate (872530-81-9)

Guidance literature:

In ethanol; at 80 ℃; for 1.5h;

DOI:10.1021/jm0508639

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate (872530-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / sulfur; morpholine / ethanol / 5 h / 45 °C

2: 94 percent / ethanol / 1.5 h / 80 °C

With morpholine; sulfur; In ethanol;

DOI:10.1021/jm0508639

Reference yield:

cyanoacetic acid tert-butyl ester (1116-98-9) → tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate (872530-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / sulfur; morpholine / ethanol / 5 h / 45 °C

2: 94 percent / ethanol / 1.5 h / 80 °C

With morpholine; sulfur; In ethanol;

DOI:10.1021/jm0508639

upstream raw materials:

tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

phenyl isothiocyanate

1-phenylmethyl-4-piperidone

cyanoacetic acid tert-butyl ester

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