tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Base Information

• Chemical Name: tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
• CAS No.: 872530-68-2
• Molecular Formula: C₁₉H₂₄N₂O₂S
• Molecular Weight: 344.478

Synonyms:tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Chemical Property of tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

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Technology Process of tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

There total 1 articles about tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-phenylmethyl-4-piperidone (3612-20-2) + cyanoacetic acid tert-butyl ester (1116-98-9) → tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (872530-68-2)

Guidance literature:

With morpholine; sulfur; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2020.112387

Reference yield: 94.0%

tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (872530-68-2) + phenyl isothiocyanate (103-72-0) → tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate (872530-81-9)

Guidance literature:

In ethanol; at 80 ℃; for 1.5h;

DOI:10.1021/jm0508639

Reference yield: 90.0%

tert-butyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (872530-68-2) + Trichloroacetyl isocyanate (3019-71-4) → tert-butyl 6-benzyl-2-(3-trichloroacetylureido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (872530-89-7)

Guidance literature:

In tetrahydrofuran; at 0 - 10 ℃; for 3h;

DOI:10.1021/jm0508639

upstream raw materials:

1-phenylmethyl-4-piperidone

cyanoacetic acid tert-butyl ester

Downstream raw materials:

tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-phenylthioureido)thieno[2,3-c]pyridine-3-carboxylate

tert-butyl 6-benzyl-2-(3-cyclohexylureido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

tert-butyl 6-benzyl-4,5,6,7-tetrahydro-2-(3-isopropylureido)thieno[2,3-c]pyridine-3-carboxylate

tert-butyl 6-benzyl-2-(3-trichloroacetylureido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

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