1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl

Base Information

Chemical Name:1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl
CAS No.:925204-63-3
Molecular Formula:C₄₈H₅₉N₅O
Molecular Weight:722.029
Hs Code.:

1'-(4-{3-[4-(1-trityl-1<i>H</i>-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl

Synonyms:1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl

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Chemical Property of 1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl

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Technology Process of 1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl

There total 4 articles about 1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 151070-87-0
4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine

: 925204-63-3
1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 110 °C

2: LiAlH₄ / tetrahydrofuran

3: 90 percent / 1,1'-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

4: NaBH(OAc)3 / CH₂Cl₂

With lithium aluminium tetrahydride; tributylphosphine; sodium tris(acetoxy)borohydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.10.087

Reference yield:

: 877142-02-4
3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol

: 925204-63-3
1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 1,1'-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

2: NaBH(OAc)3 / CH₂Cl₂

With tributylphosphine; sodium tris(acetoxy)borohydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.10.087

Reference yield:

: 224168-91-6
3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propionic acid methyl ester

: 925204-63-3
1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran

2: 90 percent / 1,1'-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

3: NaBH(OAc)3 / CH₂Cl₂

With lithium aluminium tetrahydride; tributylphosphine; sodium tris(acetoxy)borohydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.10.087