(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarbaldehyde

Base Information

Chemical Name:(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarbaldehyde
CAS No.:1256384-19-6
Molecular Formula:C₃₈H₄₄N₆O₆
Molecular Weight:680.804
Hs Code.:

Synonyms:(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarbaldehyde

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Chemical Property of (S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarbaldehyde

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Technology Process of (S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarbaldehyde

There total 3 articles about (S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256384-17-4
(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl

: 1256384-19-6
(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarbaldehyde

Guidance literature:: (S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl; With dimethyl sulfoxide; triethylamine; for 0.0833333h;

With sulfur trioxide pyridine complex; for 1.5h;

With water;

Reference yield:

: 1256384-11-8
(S)-2-(5-(4-bromo-3-methoxycarbonylphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1256384-19-6
(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 7 h / 80 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 5 h / -78 - 25 °C

2.2: 0 °C / pH 11

3.1: dimethyl sulfoxide; triethylamine / 0.08 h

3.2: 1.5 h

With diisobutylaluminium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 1256384-13-0
(S)-2-(5-(3-methoxycarbonyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1256384-19-6
(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 7 h / 80 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 5 h / -78 - 25 °C

2.2: 0 °C / pH 11

3.1: dimethyl sulfoxide; triethylamine / 0.08 h

3.2: 1.5 h

With diisobutylaluminium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; water;