(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl

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Chemical Name:(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl
CAS No.:1256384-17-4
Molecular Formula:C₃₈H₄₈N₆O₆
Molecular Weight:684.836
Hs Code.:

Synonyms:(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl

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Chemical Property of (S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl

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Technology Process of (S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl

There total 3 articles about (S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256384-15-2
(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarboxylic acid dimethyl ester

: 1256384-17-4
(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl

Guidance literature:: (S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)biphenyl-2,2'-dicarboxylic acid dimethyl ester; With diisobutylaluminium hydride; In tetrahydrofuran; at -78 - 25 ℃; for 5h;

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; pH=11;

Reference yield:

: 1256384-11-8
(S)-2-(5-(4-bromo-3-methoxycarbonylphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1256384-17-4
(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 7 h / 80 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 5 h / -78 - 25 °C

2.2: 0 °C / pH 11

With diisobutylaluminium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 1256384-13-0
(S)-2-(5-(3-methoxycarbonyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1256384-17-4
(S,S)-4,4'-bis(2-(1-tert-butoxycarbonylpyrrolidin-2-yl)-3H-imidazol-4-yl)-2,2'-bis(hydroxymethyl)biphenyl

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 7 h / 80 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 5 h / -78 - 25 °C

2.2: 0 °C / pH 11

With diisobutylaluminium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; water;