(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-1-yl)-oxo-acetyl chloride

Base Information

Chemical Name:(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-1-yl)-oxo-acetyl chloride
CAS No.:1026327-65-0
Molecular Formula:C₃₃H₂₆ClNO₃
Molecular Weight:520.027
Hs Code.:

Synonyms:(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-1-yl)-oxo-acetyl chloride

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Chemical Property of (8-Benzyloxy-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-1-yl)-oxo-acetyl chloride

Chemical Property:

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Technology Process of (8-Benzyloxy-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-1-yl)-oxo-acetyl chloride

There total 10 articles about (8-Benzyloxy-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-1-yl)-oxo-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 1026327-65-0
(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-1-yl)-oxo-acetyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / Et₃N / 90 °C

2: 50percent aq. KOH / dimethylsulfoxide / 140 °C

3: toluene / 1 h / Heating

4: 91 percent / NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

5: tetrahydrofuran / 0 °C

With potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/jm960395q

Reference yield:

: 69267-75-0
2-bromo-1-cyclopropylethan-1-one

: 1026327-65-0
(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-1-yl)-oxo-acetyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / NaHCO₃ / butan-2-one / Heating

2: 52 percent / Et₃N / 90 °C

3: 50percent aq. KOH / dimethylsulfoxide / 140 °C

4: toluene / 1 h / Heating

5: 91 percent / NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

6: tetrahydrofuran / 0 °C

With potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; toluene; butanone;
DOI:10.1021/jm960395q

Reference yield:

: 2584-12-5
ethyl 3-hydroxy-2-pyridineacetate

: 1026327-65-0
(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-1-yl)-oxo-acetyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) 60percent NaH / 1.) DMF, 0 deg C, 50 min, 2.) DMF, overnight

2: 78 percent / NaHCO₃ / butan-2-one / Heating

3: 52 percent / Et₃N / 90 °C

4: 50percent aq. KOH / dimethylsulfoxide / 140 °C

5: toluene / 1 h / Heating

6: 91 percent / NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

7: tetrahydrofuran / 0 °C

With potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; sodium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; toluene; butanone;
DOI:10.1021/jm960395q