1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate

Base Information

• Chemical Name: 1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate
• CAS No.: 60284-76-6
• Molecular Formula: C₂H₂O₄*C₃₀H₃₅NO₄
• Molecular Weight: 563.648
• Mol file: 60284-76-6.mol

Synonyms:1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate

Chemical Property of 1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate

There total 6 articles about 1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

4-(3-chloropropoxy)-3-methoxyacetophenone (58113-30-7) + C18H21NO (115-46-8) + oxalic acid (144-62-7,97993-78-7) → 1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate (60284-76-6)

Guidance literature:

With sodium carbonate; potassium iodide; 1) n-butanol, reflux;

DOI:10.1021/jm00121a022

Reference yield:

4-(3-chloropropoxy)-3-methoxyacetophenone (58113-30-7) + C18H21NO (115-46-8) → 1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate (60284-76-6)

Guidance literature:

With sodium hydrogencarbonate; In N-methyl-acetamide; benzene-isooctane;

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate (60284-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux; 2) THF, room temperature, overnight

2: 99 percent / H₂ / 5percent Pd/C / ethanol / 70 °C / 2585.7 Torr

3: 39 percent / 1) Na₂CO₃, KI / 1) n-butanol, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00121a022

upstream raw materials:

4-(3-chloropropoxy)-3-methoxyacetophenone

C₁₈H₂₁NO

oxalic acid

bromobenzene

Refernces

• 1、 -. "Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment". . . Retrieved 2008/06/13.