N-(3-chloro-3-phenylpropyl)-9,10-dihydro-N-methyl-9-oxoacridine-4-carboxamide

Base Information

Chemical Name:N-(3-chloro-3-phenylpropyl)-9,10-dihydro-N-methyl-9-oxoacridine-4-carboxamide
CAS No.:1250437-84-3
Molecular Formula:C₂₄H₂₁ClN₂O₂
Molecular Weight:404.896
Hs Code.:

Synonyms:N-(3-chloro-3-phenylpropyl)-9,10-dihydro-N-methyl-9-oxoacridine-4-carboxamide

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Chemical Property of N-(3-chloro-3-phenylpropyl)-9,10-dihydro-N-methyl-9-oxoacridine-4-carboxamide

Chemical Property:

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Technology Process of N-(3-chloro-3-phenylpropyl)-9,10-dihydro-N-methyl-9-oxoacridine-4-carboxamide

There total 7 articles about N-(3-chloro-3-phenylpropyl)-9,10-dihydro-N-methyl-9-oxoacridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 57256-93-6
N-methyl-3-chloro-3-phenylpropylamine

: 9,10-dihydro-9-oxoacridine-4-carbonyl chloride

: 1250437-84-3
N-(3-chloro-3-phenylpropyl)-9,10-dihydro-N-methyl-9-oxoacridine-4-carboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 0.233333h; Microwave irradiation;
DOI:10.2174/157018011794578169

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1250437-84-3
N-(3-chloro-3-phenylpropyl)-9,10-dihydro-N-methyl-9-oxoacridine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper; potassium carbonate / ethanol / 6 h / Reflux

1.2: 20 - 25 °C

2.1: sulfuric acid / 4 h / 100 °C

3.1: thionyl chloride; N,N-dimethyl-formamide / 2 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 70 °C

With thionyl chloride; sulfuric acid; copper; potassium carbonate; N,N-dimethyl-formamide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/cjoc.201190113

Reference yield:

: 936-59-4
3-chloropropiophenone

: 1250437-84-3
N-(3-chloro-3-phenylpropyl)-9,10-dihydro-N-methyl-9-oxoacridine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 0.67 h / 20 °C

2: sodium iodide / acetone / 12 h / Reflux

3: tetrahydrofuran / 20 °C

4: thionyl chloride / chloroform / 5 h / 60 °C / Cooling

5: potassium carbonate / N,N-dimethyl-formamide / 5 h / 70 °C

With sodium tetrahydroborate; thionyl chloride; potassium carbonate; sodium iodide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1002/cjoc.201190113