tert-butyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Chemical Name:tert-butyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
CAS No.:1400285-59-7
Molecular Formula:C₂₄H₂₄ClN₅O₄
Molecular Weight:481.939
Hs Code.:

Synonyms:tert-butyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Chemical Property of tert-butyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Technology Process of tert-butyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

There total 11 articles about tert-butyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1019018-13-3
4-amino-3-chloro-N,N-dimethylbenzamide

: 1400287-60-6
tert-butyl 6-bromo-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 1400285-59-7
tert-butyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm401395s

Reference yield:

: 1400287-58-2
6-bromo-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

: 1400285-59-7
tert-butyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / methanol / 1.83 h / 65 °C

2: triethylamine; dmap / ethyl acetate / 20 - 25 °C

3: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl acetamide / 3 h / 80 °C / Inert atmosphere

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; N,N-dimethyl acetamide; ethyl acetate;
DOI:10.1021/jm401395s

Reference yield:

: 1400287-56-0
6-bromo-2-(diethoxymethyl)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridine

: 1400285-59-7
tert-butyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / water; methanol / 6 h / 25 °C

2: toluene-4-sulfonic acid / tetrahydrofuran; water / 0.92 h / 25 °C

3: potassium carbonate / methanol / 1.83 h / 65 °C

4: triethylamine; dmap / ethyl acetate / 20 - 25 °C

5: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl acetamide / 3 h / 80 °C / Inert atmosphere

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; ethyl acetate;
DOI:10.1021/jm401395s