(S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-3-(isopropylamino)propan-2-ol

Base Information

• Chemical Name: (S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-3-(isopropylamino)propan-2-ol
• CAS No.: 116586-82-4
• Molecular Formula: C₁₅H₂₃NO₄
• Molecular Weight: 281.352
• Mol file: 116586-82-4.mol

Synonyms:(S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-3-(isopropylamino)propan-2-ol

Chemical Property of (S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-3-(isopropylamino)propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-3-(isopropylamino)propan-2-ol

There total 6 articles about (S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-3-(isopropylamino)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-2,3-epoxypropane (116662-70-5) + isopropylamine (75-31-0) → (S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-3-(isopropylamino)propan-2-ol (116586-82-4)

Guidance literature:

In water; for 5h; Heating;

DOI:10.1016/j.bmc.2004.10.057

Reference yield:

4-hydroxyphenylacetate (156-38-7) → (S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-3-(isopropylamino)propan-2-ol (116586-82-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 5.81 g / thionylchloride / 6 h / Heating

2: 87 percent / potassium carbonate / acetone / 7 h / Heating

3: 84 percent / meta-chloroperbenzoic acid / CH₂Cl₂ / 15 h / 20 °C

4: 78 percent / H₂O / 5 h / Heating

With thionyl chloride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; acetone;

DOI:10.1016/j.bmc.2004.10.057

Reference yield:

(4-hydroxyphenyl)thioacetomorpholide (781654-24-8) → (S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-3-(isopropylamino)propan-2-ol (116586-82-4)

Guidance literature:

Multi-step reaction with 5 steps

1: NaOH / ethanol; H₂O / 10 h / Heating

2: 5.81 g / thionylchloride / 6 h / Heating

3: 87 percent / potassium carbonate / acetone / 7 h / Heating

4: 84 percent / meta-chloroperbenzoic acid / CH₂Cl₂ / 15 h / 20 °C

5: 78 percent / H₂O / 5 h / Heating

With sodium hydroxide; thionyl chloride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; acetone;

DOI:10.1016/j.bmc.2004.10.057

upstream raw materials:

(S)-1-[4-(methoxycarbonylmethyl)-phenoxy]-2,3-epoxypropane

isopropylamine

4-hydroxyphenylacetate

(4-hydroxyphenyl)thioacetomorpholide

Downstream raw materials:

(S)-Atenolol