triethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,4,5-tricarboxylate

Base Information

• Chemical Name: triethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,4,5-tricarboxylate
• CAS No.: 1190383-81-3
• Molecular Formula: C₂₂H₂₇NO₆
• Molecular Weight: 401.459
• Mol file: 1190383-81-3.mol

Synonyms:triethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,4,5-tricarboxylate

Chemical Property of triethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,4,5-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of triethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,4,5-tricarboxylate

There total 3 articles about triethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,4,5-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl acetoacetate (141-97-9) + ethyl 2-(phenylimino)acetate (121642-09-9,84484-31-1) → triethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,4,5-tricarboxylate (1190383-81-3)

Guidance literature:

With copper(ll) bromide; at 20 ℃; for 18h; Neat (no solvent);

DOI:10.2174/157017809787893082

Reference yield: 78.0%

glyoxylic acid ethyl ester (924-44-7) + ethyl acetoacetate (141-97-9) + aniline (62-53-3) → triethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,4,5-tricarboxylate (1190383-81-3)

Guidance literature:

With montmorillonite K-10; at 20 ℃; Green chemistry;

DOI:10.1016/j.tet.2013.04.006

Reference yield: 56.0%

N-phenylglycine ethyl ester (2216-92-4) + ethyl acetoacetate (141-97-9) → triethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,4,5-tricarboxylate (1190383-81-3)

Guidance literature:

With tris[2-phenylpyridinato-C₂,N]iridium(III); bis(1-methyl-1-phenylethyl)peroxide; In toluene; at 20 ℃; for 12h; Irradiation;

DOI:10.1016/j.tet.2020.131353

upstream raw materials:

ethyl acetoacetate

ethyl 2-(phenylimino)acetate

glyoxylic acid ethyl ester

aniline