2,2-DI(ACETOXYMETHYL)PROPIONYL CHLORIDE

Base Information

• Chemical Name: 2,2-DI(ACETOXYMETHYL)PROPIONYL CHLORIDE
• CAS No.: 17872-59-2
• Molecular Formula: C9H13 Cl O5
• Molecular Weight: 236.652
• Hs Code.: 2915900090
• Mol file: 17872-59-2.mol

Synonyms:Propionylchloride, 2,2-bis(hydroxymethyl)-, diacetate (8CI);2,2-Bis(acetoxymethyl)propanoyl chloride; 2,2-Bis(acetoxymethyl)propionylchloride

Chemical Property of 2,2-DI(ACETOXYMETHYL)PROPIONYL CHLORIDE

Chemical Property:

• PSA: 69.67000
• LogP: 0.88430

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DI(ACETOXYMETHYL)PROPIONYL CHLORIDE

There total 3 articles about 2,2-DI(ACETOXYMETHYL)PROPIONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2-bis(acetoxymethyl)propionic acid (17872-58-1) → 2,2-bis(acetoxymethyl)propanoic acid chloride (17872-59-2)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1021/ja954171t

Reference yield:

2,2-bis(hydroxymethyl)propionic acid (4767-03-7) → 2,2-bis(acetoxymethyl)propanoic acid chloride (17872-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / Et₃N, DMAP / CH₂Cl₂ / 0.5 h

2: 99 percent / (COCl)2, DMF / CH₂Cl₂ / 2 h / 25 °C

With dmap; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/ja954171t

Reference yield:

→ 2,2-bis(acetoxymethyl)propanoic acid chloride (17872-59-2)

Guidance literature:

entspr. Carbonsaeure, SOCl2;

upstream raw materials:

2,2-bis(acetoxymethyl)propionic acid

2,2-bis(hydroxymethyl)propionic acid

Downstream raw materials:

3-(3-Acetoxy-2-acetoxymethyl-2-methyl-propionyloxy)-2-(3-acetoxy-2-acetoxymethyl-2-methyl-propionyloxymethyl)-2-methyl-propionic acid benzyl ester

C₅₈H₈₀O₃₀

Refernces

• 1、 Ihre, Henrik,Hult, Anders,S?derlind, Erik. "Synthesis, characterization, and 1H NMR self-diffusion studies of dendritic aliphatic polyesters based on 2,2-bis(hydroxymethyl)propionic acid and 1,1,1-tris(hydroxyphenyl)ethane". . p. 6388 - 6395. Retrieved 2007/10/03.