3-phenyl-propionic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester

Base Information

• Chemical Name: 3-phenyl-propionic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester
• CAS No.: 1100308-48-2
• Molecular Formula: C₁₈H₂₇NO₂
• Molecular Weight: 289.418
• Mol file: 1100308-48-2.mol

Synonyms:3-phenyl-propionic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester

Chemical Property of 3-phenyl-propionic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-phenyl-propionic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester

There total 2 articles about 3-phenyl-propionic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

3-phenyl-propionaldehyde (104-53-0) + 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) → 2,2,6,6-tetramethylpiperidin-1-ol (7031-93-8) + 3-phenyl-propionic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester (1100308-48-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-dimethyl-1,2,4-triazolium iodide; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.200802735

Reference yield:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + 2-oxo-4-phenyl-butyronitrile (66582-22-7) → 3-phenyl-propionic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester (1100308-48-2) + 2,2,6,6-tetramethyl-1-(2-phenylethoxy)piperidine (131428-11-0)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; N,N-dimethyl-aniline; In water; tert-butyl alcohol; at 60 ℃; for 36h;

DOI:10.1002/chem.201303296

upstream raw materials:

3-phenyl-propionaldehyde

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

2-oxo-4-phenyl-butyronitrile