7-chloro-3-[4-(2-hydroxyethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester

Base Information

Chemical Name:7-chloro-3-[4-(2-hydroxyethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester
CAS No.:1080674-14-1
Molecular Formula:C₂₇H₂₃ClN₂O₅
Molecular Weight:490.943
Hs Code.:

Synonyms:7-chloro-3-[4-(2-hydroxyethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester

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Chemical Property of 7-chloro-3-[4-(2-hydroxyethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester

Chemical Property:

Boiling Point:713.6±60.0 °C(Predicted)
Density:1.365±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 7-chloro-3-[4-(2-hydroxyethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester

There total 3 articles about 7-chloro-3-[4-(2-hydroxyethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080674-06-1
3-(4-carboxy-benzyl)-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

: 141-43-5
ethanolamine

: 1080674-14-1
7-chloro-3-[4-(2-hydroxyethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1080674-98-1
1-(4-chloro-2-phenylamino-phenyl)-ethanone

: 1080674-14-1
7-chloro-3-[4-(2-hydroxyethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / methanol / 20 °C

2: hydrogen; 10% Pd/C / tetrahydrofuran; ethyl acetate

3: toluene / 4 h / 20 °C

4: sodium hexamethyldisilazane / methanol

With 10% Pd/C; hydrogen; sodium hexamethyldisilazane; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate; toluene; 1: |Aldol Condensation;
DOI:10.1016/j.bmcl.2012.10.066

Reference yield:

: C₂₄H₂₁ClN₂O₃

: 1080674-14-1
7-chloro-3-[4-(2-hydroxyethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; 10% Pd/C / tetrahydrofuran; ethyl acetate

2: toluene / 4 h / 20 °C

3: sodium hexamethyldisilazane / methanol

With 10% Pd/C; hydrogen; sodium hexamethyldisilazane; In tetrahydrofuran; methanol; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2012.10.066