2-Acetamidonicotinic acid

Base Information

• Chemical Name: 2-Acetamidonicotinic acid
• CAS No.: 17782-03-5
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.163
• Hs Code.: 29339900
• Mol file: 17782-03-5.mol

Synonyms:Nicotinicacid, 2-acetamido- (8CI); 2-Acetamidonicotinic acid

Chemical Property of 2-Acetamidonicotinic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• Boiling Point: 465.2°Cat760mmHg
• Flash Point: 235.1°C
• PSA: 79.29000
• Density: 1.404g/cm³
• LogP: 0.81120

Purity/Quality:

98% ^*data from raw suppliers

2-Acetamidopyridine-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Acetamidonicotinic acid

There total 7 articles about 2-Acetamidonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-aminopyridin-3-carboxylic acid (5345-47-1) + acetic anhydride (108-24-7) → 2-acetamidonicotinic acid (17782-03-5)

Guidance literature:

at 110 ℃; for 4h;

Reference yield:

nicotinic acid (59-67-6) → 2-acetamidonicotinic acid (17782-03-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / 30percent H₂O₂ / acetic acid / 3 h / 90 °C

2: PCl₅, POCl₃

3: 60 percent / conc. NH₄OH / 20 h / 155 °C

4: 70 percent / 4 h / 110 °C

With ammonium hydroxide; phosphorus pentachloride; dihydrogen peroxide; trichlorophosphate; In acetic acid;

Reference yield:

Nicotinic acid N-oxide (2398-81-4) → 2-acetamidonicotinic acid (17782-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1: PCl₅, POCl₃

2: 60 percent / conc. NH₄OH / 20 h / 155 °C

3: 70 percent / 4 h / 110 °C

With ammonium hydroxide; phosphorus pentachloride; trichlorophosphate;

upstream raw materials:

2-aminopyridin-3-carboxylic acid

acetic anhydride

2-Methyl-4H-pyrido<2,3-d><3,1>oxazin-4-one

nicotinic acid

Downstream raw materials:

2-Methyl-3-(2'-methyl-3'-chlorphenyl)-4-oxo-3,4-dihydropyrido<2,3-d>pyrimidin

3-(2-methylphenyl)-2-styryl-pyrido<2,3-d>pyrimidin-4(3H)-one

2-(4-hydroxy-3-methoxystyryl)-3-(2-methylphenyl)pyrido<2,3-d>pyrimidin-4(3H)-one

2-(3,4-methylenedioxystyryl)-3-(2-methylphenyl)pyrido<2,3-d>pyrimidin-4(3H)-one

Refernces