3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid; hydrochloride

Base Information

Chemical Name:3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid; hydrochloride
CAS No.:120363-44-2
Molecular Formula:C₂₆H₂₈N₂O₆*ClH
Molecular Weight:500.979
Hs Code.:

Synonyms:3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid; hydrochloride

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Chemical Property of 3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid; hydrochloride

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Technology Process of 3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid; hydrochloride

There total 11 articles about 3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31493-49-9
N-(Boc)-3'-hydroxy-4'-methoxyphenethylamine

: 120363-44-2
3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

2: 100 percent / H₂ / 10percent Pd/C / methanol / 3 h / 25 °C / 2280 Torr

3: 74 percent / EtSNa / dimethylformamide / 3 h / 155 °C

4: 100 percent / H₂SO₄ / 9 h / 70 °C

5: 3.0M HCl / ethyl acetate / 25 °C

6: EDCI / dimethylformamide / 25 °C

7: LiOH, H₂O / methanol; tetrahydrofuran / 25 °C

8: 3.0M HCl / ethyl acetate

With hydrogenchloride; lithium hydroxide; sulfuric acid; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium thioethylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00311a019

Reference yield:

: 1135-15-5
dihydroisoferulic acid

: 120363-44-2
3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid; hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 63 percent / Et₃N, DPPA / 8 h / 80 °C

3: 100 percent / H₂ / 10percent Pd/C / methanol / 3 h / 25 °C / 2280 Torr

4: 74 percent / EtSNa / dimethylformamide / 3 h / 155 °C

5: 100 percent / H₂SO₄ / 9 h / 70 °C

6: 3.0M HCl / ethyl acetate / 25 °C

7: EDCI / dimethylformamide / 25 °C

8: LiOH, H₂O / methanol; tetrahydrofuran / 25 °C

9: 3.0M HCl / ethyl acetate

With hydrogenchloride; lithium hydroxide; sulfuric acid; diphenyl-phosphinic acid; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium thioethylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00311a019

Reference yield:

: 161634-73-7
trans-3-(4-iodophenyl)-2-propenoic acid ethyl ester

: 120363-44-2
3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

2: 100 percent / H₂ / 10percent Pd/C / methanol / 3 h / 25 °C / 2280 Torr

3: 74 percent / EtSNa / dimethylformamide / 3 h / 155 °C

4: 100 percent / H₂SO₄ / 9 h / 70 °C

5: 3.0M HCl / ethyl acetate / 25 °C

6: EDCI / dimethylformamide / 25 °C

7: LiOH, H₂O / methanol; tetrahydrofuran / 25 °C

8: 3.0M HCl / ethyl acetate

With hydrogenchloride; lithium hydroxide; sulfuric acid; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium thioethylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00311a019