4-benzamidophenyl-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoate

Base Information

• Chemical Name: 4-benzamidophenyl-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoate
• CAS No.: 57790-51-9
• Molecular Formula: C₃₃H₄₃NO₆
• Molecular Weight: 549.708

Synonyms:4-benzamidophenyl-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoate

Chemical Property of 4-benzamidophenyl-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoate

Chemical Property:

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Technology Process of 4-benzamidophenyl-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoate

There total 4 articles about 4-benzamidophenyl-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

ALPROSTADIL (745-65-3) + p-benzoylaminophenol (15457-50-8) → 4-benzamidophenyl-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoate (57790-51-9)

Guidance literature:

ALPROSTADIL; p-benzoylaminophenol; With dmap; In dichloromethane; at -10 ℃; for 0.05h; Inert atmosphere;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;

Reference yield:

→ 4-benzamidophenyl-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoate (57790-51-9)

Guidance literature:

PGE(1), 1) Isobutylchlorformiat, Et3N, 2) p-Benzamidophenol;

Reference yield:

→ 7-[3-Hydroxy-2-((E)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-heptanoic acid 4-benzoylamino-phenyl ester (57790-51-9)

Guidance literature:

entspr. Ester, entspr. Phenol;

upstream raw materials:

ALPROSTADIL

p-benzoylaminophenol

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