p-(N-Benzoylamino)phenol

Base Information

• Chemical Name: p-(N-Benzoylamino)phenol
• CAS No.: 15457-50-8
• Molecular Formula: C13H11 N O2
• Molecular Weight: 213.236
• Hs Code.: 2924299090
• Mol file: 15457-50-8.mol

Synonyms:Benzanilide,4'-hydroxy- (6CI,7CI,8CI); 4-(Benzoylamino)phenol; 4-(N-Benzoylamino)phenol;4-Benzamidophenol; 4'-Hydroxybenzanilide; N-(4-Hydroxyphenyl)benzamide;N-Benzoyl-4-aminophenol; N-Benzoyl-4-hydroxyaniline; p-(N-Benzoylamino)phenol;p-Benzamidophenol

Chemical Property of p-(N-Benzoylamino)phenol

Chemical Property:

• Vapor Pressure: 0.000565mmHg at 25°C
• Melting Point: 227 °C
• Boiling Point: 302.1°Cat760mmHg
• PKA: 10.26±0.26(Predicted)
• Flash Point: 136.5°C
• PSA: 49.33000
• Density: 1.278g/cm³
• LogP: 2.71750

Purity/Quality:

97% ^*data from raw suppliers

N-(4-Hydroxyphenyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-(N-Benzoylamino)phenol

There total 67 articles about p-(N-Benzoylamino)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-amino-phenol (123-30-8) + benzoic acid (65-85-0,8013-63-6) → p-benzoylaminophenol (15457-50-8)

Guidance literature:

With TEA; diphenyl (2,3-dihydro-2-thioxo-3-benzoxazolyl)phosphonate; In various solvent(s); for 2h; Ambient temperature;

DOI:10.1246/bcsj.65.1636

Reference yield: 98.0%

4-amino-phenol (123-30-8) + benzoic acid anhydride (93-97-0) → p-benzoylaminophenol (15457-50-8)

Guidance literature:

With sodium dodecyl-sulfate; In water; acetonitrile; for 0.0833333h;

DOI:10.1002/ejoc.200300620

Reference yield: 97.0%

3-benzoyl-2(3H)-benzoxazolethione (33388-23-7) + 4-amino-phenol (123-30-8) → p-benzoylaminophenol (15457-50-8)

Guidance literature:

In various solvent(s); at 15 ℃; for 0.333333h;

DOI:10.1055/s-1981-29674

upstream raw materials:

pyridine

4-amino-phenol

benzoyl chloride

(4-hydroxyphenyl)(phenyl)methanone oxime

Downstream raw materials:

4-benzoyloxy-aniline

acetic acid 4-benzoylaminophenyl ester

N-benzoyl-3,5-bis(N-pyrrolidinylmethyl)-4-hydroxyaniline

N-(benzoyl)3,5-bis(piperidinylmethyl)-4-hydroxyaniline

Refernces

• 1、 Abdallah, Abdallah E.,Mabrouk, Reda R.,Al Ward, Maged Mohammed Saleh,Eissa, Sally I.,Elkaeed, Eslam B.,Mehany, Ahmed B. M.,Abo-Saif, Mariam A.,El-Feky, Ola A.,Alesawy, Mohamed S.,El-Zahabi, Mohamed Ayman. "Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors". . p. 573 - 591. Retrieved 2022/01/20.
• 2、 Chuang, Hsiang-Yu,Schupp, Manuel,Meyrelles, Ricardo,Maryasin, Boris,Maulide, Nuno. "Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols". supporting information. p. 13778 - 13782. Retrieved 2021/03/31.