3-[3-(2-benzyloxy-ethyl)-7-chloro-4,4-dimethyl-heptanoyl]-oxazolidin-2-one

Base Information

Chemical Name:3-[3-(2-benzyloxy-ethyl)-7-chloro-4,4-dimethyl-heptanoyl]-oxazolidin-2-one
CAS No.:711028-93-2
Molecular Formula:C₂₁H₃₀ClNO₄
Molecular Weight:395.926
Hs Code.:

Synonyms:3-[3-(2-benzyloxy-ethyl)-7-chloro-4,4-dimethyl-heptanoyl]-oxazolidin-2-one

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Chemical Property of 3-[3-(2-benzyloxy-ethyl)-7-chloro-4,4-dimethyl-heptanoyl]-oxazolidin-2-one

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Technology Process of 3-[3-(2-benzyloxy-ethyl)-7-chloro-4,4-dimethyl-heptanoyl]-oxazolidin-2-one

There total 4 articles about 3-[3-(2-benzyloxy-ethyl)-7-chloro-4,4-dimethyl-heptanoyl]-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1985-91-7
4-bromo-1-chloro-4-methyl-pentane

: 147071-37-2
3-(5-benzyloxy-pent-2-(E)-enoyl)-oxazolidin-2-one

: 711028-93-2
3-[3-(2-benzyloxy-ethyl)-7-chloro-4,4-dimethyl-heptanoyl]-oxazolidin-2-one

Guidance literature:: With 1,1-di{(3aS,8aR)-indano[1,2-d][1,3]oxazolin-2-yl}cyclopropan; tri-n-butyl-tin hydride; magnesium iodide; triethyl borane; oxygen; In hexane; dichloromethane; at -78 ℃; for 6h;
DOI:10.1021/ol0495772

Reference yield:

: 7712-59-6
5-chloro-2-methylpentan-2-ol

: 711028-93-2
3-[3-(2-benzyloxy-ethyl)-7-chloro-4,4-dimethyl-heptanoyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / PBr₃; pyridine / 5.5 h / 0 - 20 °C

2: 84 percent / 1,1-di{(3aS,8aR)-indano[1,2-d][1,3]oxazolin-2-yl}cyclopropan; MgI₂; Bu₃SnH / Et₃B; O₂ / CH₂Cl₂; hexane / 6 h / -78 °C

With pyridine; 1,1-di{(3aS,8aR)-indano[1,2-d][1,3]oxazolin-2-yl}cyclopropan; tri-n-butyl-tin hydride; phosphorus tribromide; magnesium iodide; triethyl borane; oxygen; In hexane; dichloromethane;
DOI:10.1021/ol0495772

Reference yield:

: 19790-60-4
3-Benzyloxypropanal

: 711028-93-2
3-[3-(2-benzyloxy-ethyl)-7-chloro-4,4-dimethyl-heptanoyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / LiCl; diisopropylethylamine / tetrahydrofuran / 31 h / 20 °C

2: 84 percent / 1,1-di{(3aS,8aR)-indano[1,2-d][1,3]oxazolin-2-yl}cyclopropan; MgI₂; Bu₃SnH / Et₃B; O₂ / CH₂Cl₂; hexane / 6 h / -78 °C

With 1,1-di{(3aS,8aR)-indano[1,2-d][1,3]oxazolin-2-yl}cyclopropan; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; lithium chloride; magnesium iodide; triethyl borane; oxygen; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol0495772