(S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide

Base Information

Chemical Name:(S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide
CAS No.:132723-84-3
Molecular Formula:C₂₂H₃₁FNO*I
Molecular Weight:471.397
Hs Code.:

Synonyms:(S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide

Suppliers and Price of (S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide

Chemical Property:

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Technology Process of (S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide

There total 3 articles about (S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 127413-20-1
(S)-p-fluoro-Hexbutinol

: 74-88-4
methyl iodide

: 132723-84-3
(S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide

Guidance literature:: In acetone; at 30 ℃;

Reference yield:

: 5799-75-7
1-(prop-2-yn-1-yl)piperidine

: 132723-84-3
(S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi / 1) hexane, Et₂O, 2 h, -50 deg C 2) Et₂O, 16 h, r.t.

2: 89 percent / acetone / 30 °C

With n-butyllithium; In acetone;

Reference yield:

: 85014-02-4
cyclohexyl-(4-fluoromethyl)methanone

: 132723-84-3
(S)-1-Cyclohexyl-1-(4-fluorophenyl)-4-piperidino-2-butyn-1-ol methioiodide

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi / 1) hexane, Et₂O, 2 h, -50 deg C 2) Et₂O, 16 h, r.t.

2: 89 percent / acetone / 30 °C

With n-butyllithium; In acetone;