(4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene

Base Information

Chemical Name:(4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene
CAS No.:765950-82-1
Molecular Formula:C₃₅H₃₉ClO₃
Molecular Weight:543.146
Hs Code.:

Synonyms:(4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene

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Chemical Property of (4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene

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Technology Process of (4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene

There total 21 articles about (4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 765950-78-5
(4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-6a-[(phenylseleno)methyl]-4,4,12b-trimethyl-benzo[a]xanthene

: 765950-82-1
(4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 15h; Heating;
DOI:10.1021/jo0491399

Reference yield:

: 166406-74-2
(1S,3aR,5aS,9aS,9bR)-1-hydroxy-dodecahydro-3a,6,6,9a,-tetramethylnaphtho-[2,1-b]furan-2-one

: 765950-82-1
(4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene

Guidance literature:: Multi-step reaction with 12 steps

1.1: 30 percent / LiAlH₄ / tetrahydrofuran / 4 h / 25 °C

2.1: 91 percent / LiAlH₄ / tetrahydrofuran / 3 h

3.1: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C

4.1: 97 percent / LiALH₄ / diethyl ether / 1 h / 20 °C

5.1: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C

6.1: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C

7.1: 93 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h / 25 °C

8.1: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 25 °C

9.1: t-BuLi / pentane; diethyl ether / 0.5 h / -78 °C

9.2: 89 percent / pentane; diethyl ether / 2 h / -78 °C

10.1: 93 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 4 h / 0 °C

11.1: 56 percent / SnCl₄ / CH₂Cl₂ / 4 h / -78 °C

12.1: 92 percent / AIBN; n-Bu₃SnH / toluene / 15 h / Heating

With 1H-imidazole; lead(IV) acetate; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tert.-butyl lithium; tri-n-butyl-tin hydride; tin(IV) chloride; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; pentane; benzene;
DOI:10.1021/jo0491399

Reference yield:

: 564-20-5,1216-84-8,30450-17-0,58976-28-6,64090-92-2,67844-42-2,79768-41-5,79768-42-6,86688-27-9,86688-28-0,95406-08-9,98719-44-9,98719-46-1,131831-65-7,140851-80-5
(3aR)-(+)-sclareolide

: 765950-82-1
(4aS,6aS,12bS)-2H-9,10-dibenzyloxy-11-chloro-1,3,4,4a,5,6,6a,12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene

Guidance literature:: Multi-step reaction with 13 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 65.6 percent / MoO₅*pyridine*HMPA / tetrahydrofuran / 0.5 h / -78 °C

2.1: 30 percent / LiAlH₄ / tetrahydrofuran / 4 h / 25 °C

3.1: 91 percent / LiAlH₄ / tetrahydrofuran / 3 h

4.1: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C

5.1: 97 percent / LiALH₄ / diethyl ether / 1 h / 20 °C

6.1: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C

7.1: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C

8.1: 93 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h / 25 °C

9.1: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 25 °C

10.1: t-BuLi / pentane; diethyl ether / 0.5 h / -78 °C

10.2: 89 percent / pentane; diethyl ether / 2 h / -78 °C

11.1: 93 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 4 h / 0 °C

12.1: 56 percent / SnCl₄ / CH₂Cl₂ / 4 h / -78 °C

13.1: 92 percent / AIBN; n-Bu₃SnH / toluene / 15 h / Heating

With 1H-imidazole; lead(IV) acetate; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tert.-butyl lithium; tri-n-butyl-tin hydride; tin(IV) chloride; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; pentane; benzene;
DOI:10.1021/jo0491399