(S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

Base Information

Chemical Name:(S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride
CAS No.:1394849-60-5
Molecular Formula:C₁₁H₁₇NO₂*ClH
Molecular Weight:231.722
Hs Code.:

Synonyms:(S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

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Chemical Property of (S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

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Technology Process of (S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

There total 9 articles about (S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.1%

: 1394849-56-9
di-tert-butyl (S)-2-[3-(benzyloxy)-2-(hydroxymethyl)-propyl]-2-imidodicarbonate

: 1394849-60-5
(S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

Guidance literature:: With hydrogenchloride; In methanol; ethyl acetate; at 25 - 40 ℃; for 3h;
DOI:10.1021/op3001383

Reference yield:

: 117087-17-9
5-[(benzyloxy)methyl]-2,2-dimethyl-1,3-dioxane

: 1394849-60-5
(S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride / water; isopropyl alcohol / 3 h / 25 °C / Large scale

2: Lipase AS Amano from (Aspergillus niger) / dimethyl sulfoxide / 20 h / 37 °C / pH 7.5 / Enzymatic reaction

3: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / -20 °C

4: potassium carbonate / methanol / 1 h / 25 °C

5: triethylamine / toluene / 1 h / -5 - 5 °C

6: caesium carbonate / 6 h / 25 - 75 °C

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 25 °C

8: hydrogenchloride / methanol; ethyl acetate / 3 h / 25 - 40 °C

With 2,6-dimethylpyridine; hydrogenchloride; Lipase AS Amano from (Aspergillus niger); tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1021/op3001383

Reference yield:

: 117087-18-0
2-((benzyloxy)methyl)propane-1,3-diol

: 1394849-60-5
(S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: Lipase AS Amano from (Aspergillus niger) / dimethyl sulfoxide / 20 h / 37 °C / pH 7.5 / Enzymatic reaction

2: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / -20 °C

3: potassium carbonate / methanol / 1 h / 25 °C

4: triethylamine / toluene / 1 h / -5 - 5 °C

5: caesium carbonate / 6 h / 25 - 75 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 25 °C

7: hydrogenchloride / methanol; ethyl acetate / 3 h / 25 - 40 °C

With 2,6-dimethylpyridine; hydrogenchloride; Lipase AS Amano from (Aspergillus niger); tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1021/op3001383