(S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate

Base Information

Chemical Name:(S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate
CAS No.:1394849-52-5
Molecular Formula:C₁₉H₃₂O₄Si
Molecular Weight:352.546
Hs Code.:

Synonyms:(S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate

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Chemical Property of (S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate

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Technology Process of (S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate

There total 4 articles about (S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

: 138435-91-3
(S)-3-(benzyloxy)-2-(hydroxymethyl)propyl acetate

: 69739-34-0
t-butyldimethylsiyl triflate

: 1394849-52-5
(S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate

Guidance literature:: With 2,6-dimethylpyridine; In tetrahydrofuran; at -20 ℃; for 1h;
DOI:10.1021/op3001383

Reference yield:

: 117087-17-9
5-[(benzyloxy)methyl]-2,2-dimethyl-1,3-dioxane

: 1394849-52-5
(S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; isopropyl alcohol / 3 h / 25 °C / Large scale

2: Lipase AS Amano from (Aspergillus niger) / dimethyl sulfoxide / 20 h / 37 °C / pH 7.5 / Enzymatic reaction

3: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / -20 °C

With 2,6-dimethylpyridine; hydrogenchloride; Lipase AS Amano from (Aspergillus niger); In tetrahydrofuran; water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/op3001383

Reference yield:

: 117087-18-0
2-((benzyloxy)methyl)propane-1,3-diol

: 1394849-52-5
(S)-3-(benzyloxy)-2-({[tert-butyl(dimethyl)silyl]oxy}-methyl)propyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: Lipase AS Amano from (Aspergillus niger) / dimethyl sulfoxide / 20 h / 37 °C / pH 7.5 / Enzymatic reaction

2: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / -20 °C

With 2,6-dimethylpyridine; Lipase AS Amano from (Aspergillus niger); In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/op3001383