dihydro-5(S)-<<<(trifluoromethyl)sulfonyl>oxy>methyl>-3(R)-(phenylmethyl)-3(2H)-furanone

Base Information

Chemical Name:dihydro-5(S)-<<<(trifluoromethyl)sulfonyl>oxy>methyl>-3(R)-(phenylmethyl)-3(2H)-furanone
CAS No.:150323-33-4
Molecular Formula:C₁₃H₁₃F₃O₅S
Molecular Weight:338.304
Hs Code.:

Synonyms:dihydro-5(S)-<<<(trifluoromethyl)sulfonyl>oxy>methyl>-3(R)-(phenylmethyl)-3(2H)-furanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dihydro-5(S)-<<<(trifluoromethyl)sulfonyl>oxy>methyl>-3(R)-(phenylmethyl)-3(2H)-furanone

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Technology Process of dihydro-5(S)-<<<(trifluoromethyl)sulfonyl>oxy>methyl>-3(R)-(phenylmethyl)-3(2H)-furanone

There total 5 articles about dihydro-5(S)-<<<(trifluoromethyl)sulfonyl>oxy>methyl>-3(R)-(phenylmethyl)-3(2H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 150407-67-3
dihydro-5(S)-(hydroxymethyl)-3(R)-(phenylmethyl)-3(2H)-furanone

: 150323-33-4
dihydro-5(S)-<<<(trifluoromethyl)sulfonyl>oxy>methyl>-3(R)-(phenylmethyl)-3(2H)-furanone

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jm00047a001

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 150323-33-4
dihydro-5(S)-<<<(trifluoromethyl)sulfonyl>oxy>methyl>-3(R)-(phenylmethyl)-3(2H)-furanone

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / imidazole / CH₂Cl₂ / 4 h / 0 - 20 °C

2: 1.) LDA / 1.) THF, hexane, 30 min, 2.) THF, hexane, 3 h

3: 97 percent / 49percent aq. HF / acetonitrile / 18 h / Ambient temperature

4: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; hydrogen fluoride; lithium diisopropyl amide; In dichloromethane; acetonitrile;
DOI:10.1021/jm00047a001