Technology Process of H-ACHPA-Ile 3-(pyridylmethyl)amide dihydrochloride
There total 5 articles about H-ACHPA-Ile 3-(pyridylmethyl)amide dihydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; methanol;
for 1h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / N-methylmorpholine, 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 8 h / Ambient temperature
2: 96 percent / 4 N HCl / dioxane; methanol / 1 h / Ambient temperature
3: 89 percent / N-methylmorpholine, 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 12 h / Ambient temperature
4: 95 percent / 4 N HCl / dioxane; methanol / 1 h / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / N-methylmorpholine, 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 8 h / Ambient temperature
2: 96 percent / 4 N HCl / dioxane; methanol / 1 h / Ambient temperature
3: 89 percent / N-methylmorpholine, 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 12 h / Ambient temperature
4: 95 percent / 4 N HCl / dioxane; methanol / 1 h / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide;
