(S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:177914-12-4
Molecular Formula:C₂₉H₄₁N₃O₆
Molecular Weight:527.661
Hs Code.:

(S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 4 articles about (S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: (S)-((R)-2-Amino-2-cyclopentyl-acetylamino)-cyclopropyl-acetic acid benzyl ester; hydrochloride

: 177914-12-4
(S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm9600914

Reference yield:

: 177914-10-2
(S)-((R)-2-tert-Butoxycarbonylamino-2-cyclopentyl-acetylamino)-cyclopropyl-acetic acid benzyl ester

: 177914-12-4
(S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 4N aq. HCl / ethyl acetate / 1 h / Ambient temperature

2: 100 percent / EDCI, HOBT, NMM / dimethylformamide / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9600914

Reference yield:

: 156881-63-9
(R)-2-((tertbutoxycarbonyl)amino)-2-cyclopentylacetic acid

: 177914-12-4
(S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / EDCI, HOBT, NMM / dimethylformamide / Ambient temperature

2: 100 percent / 4N aq. HCl / ethyl acetate / 1 h / Ambient temperature

3: 100 percent / EDCI, HOBT, NMM / dimethylformamide / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9600914