5-Phenyl-8-methoxy-quinoline

Base Information

• Chemical Name: 5-Phenyl-8-methoxy-quinoline
• CAS No.: 116633-03-5
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.285
• DSSTox Substance ID: DTXSID901310095
• Mol file: 116633-03-5.mol

Synonyms:8-methoxy-5-phenylquinoline;5-Phenyl-8-methoxy-quinoline;SCHEMBL8041159;DTXSID901310095;116633-03-5

Chemical Property of 5-Phenyl-8-methoxy-quinoline

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 235.099714038
• Heavy Atom Count: 18
• Complexity: 262

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C2C(=C(C=C1)C3=CC=CC=C3)C=CC=N2

Technology Process of 5-Phenyl-8-methoxy-quinoline

There total 7 articles about 5-Phenyl-8-methoxy-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromo-8-methoxyquinoline (10522-47-1) + phenylboronic acid (98-80-6) → 8-methoxy-5-phenylquinoline (116633-03-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 12h;

DOI:10.1055/a-1506-3884

Reference yield:

8-hydroxy-5-(phenyl)quinoline (15657-87-1) + methyl iodide (74-88-4) → 8-methoxy-5-phenylquinoline (116633-03-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1002/adsc.201900839

Reference yield:

8-methoxyquinoline (938-33-0) → 8-methoxy-5-phenylquinoline (116633-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 24 h / 20 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 12 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; acetonitrile;

DOI:10.1055/a-1506-3884

upstream raw materials:

5-bromo-8-methoxyquinoline

phenylboronic acid

5-bromo-8-hydroxyquinoline

8-hydroxy-5-(phenyl)quinoline

Downstream raw materials:

8-hydroxy-5-(phenyl)quinoline