Technology Process of 4-chloro-2-allylbenzonitrile
There total 2 articles about 4-chloro-2-allylbenzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-bromo-4-chloro-benzonitrile;
With
n-butyl magnesium bromide; n-butyllithium;
In
tetrahydrofuran; hexane;
at -50 ℃;
for 0.0833333h;
Inert atmosphere;
allyl bromide;
With
copper(I) cyanide di(lithium chloride);
In
tetrahydrofuran; hexane;
for 0.166667h;
Inert atmosphere;
With
water; ammonium chloride;
In
tetrahydrofuran; hexane;
DOI:10.1021/ja1052126
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium diacetate; N-Bromosuccinimide / 1,2-dichloro-ethane / Inert atmosphere; Schlenk technique
2: n-butyl magnesium bromide; lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Schlenk technique
With
n-butyl magnesium bromide; N-Bromosuccinimide; lithium aluminium tetrahydride; palladium diacetate;
In
tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1002/anie.201405401
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 0 ℃;
for 1.25h;
Inert atmosphere;
DOI:10.1021/ja1052126
