Technology Process of (R)-(6-benzyloxy)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)chroman
There total 10 articles about (R)-(6-benzyloxy)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)chroman which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)chroman-6-ol;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
benzyl bromide;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: potassium carbonate / acetonitrile / 20 °C / Reflux
2.1: 16 h / 200 °C / Inert atmosphere
3.1: potassium carbonate / acetone / 6 h / Reflux
4.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 4 h / 20 °C
4.2: 6 h / Reflux
5.1: pyridinium chlorochromate / dichloromethane / 5 h / 0 - 20 °C / Molecular sieve
6.1: dichloromethane / 18 h / 20 °C
7.1: diisobutylaluminium hydride / toluene / 4 h / 0 - 20 °C / Inert atmosphere
8.1: titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; decane / 18 h / -25 °C / Molecular sieve
9.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C
9.2: 3 h / 0 °C
9.3: 0.67 h / 0 - 20 °C
10.1: toluene-4-sulfonic acid / 0.5 h / 20 °C
11.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; hydrogen; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; 9-borabicyclo[3.3.1]nonane; pyridinium chlorochromate;
palladium 10% on activated carbon;
In
tetrahydrofuran; decane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
2.1: Claisen Rearrangement / 6.1: Wittig Reaction / 8.1: Sharpless Epoxidation;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 16 h / 200 °C / Inert atmosphere
2.1: potassium carbonate / acetone / 6 h / Reflux
3.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 4 h / 20 °C
3.2: 6 h / Reflux
4.1: pyridinium chlorochromate / dichloromethane / 5 h / 0 - 20 °C / Molecular sieve
5.1: dichloromethane / 18 h / 20 °C
6.1: diisobutylaluminium hydride / toluene / 4 h / 0 - 20 °C / Inert atmosphere
7.1: titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; decane / 18 h / -25 °C / Molecular sieve
8.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C
8.2: 3 h / 0 °C
8.3: 0.67 h / 0 - 20 °C
9.1: toluene-4-sulfonic acid / 0.5 h / 20 °C
10.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; hydrogen; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; 9-borabicyclo[3.3.1]nonane; pyridinium chlorochromate;
palladium 10% on activated carbon;
In
tetrahydrofuran; decane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;
1.1: Claisen Rearrangement / 5.1: Wittig Reaction / 7.1: Sharpless Epoxidation;
