4-(2-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine

Base Information

Chemical Name:4-(2-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine
CAS No.:1020173-17-4
Molecular Formula:C₁₈H₂₅FN₂O₂Si
Molecular Weight:348.493
Hs Code.:

Synonyms:4-(2-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine

Chemical Property:

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Technology Process of 4-(2-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine

There total 2 articles about 4-(2-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1020173-16-3
(4-(4-amino-3-fluorophenoxy)pyridin-2-yl)methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1020173-17-4
4-(2-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1020173-15-2
tert-butyl 4-(4-amino-3-fluorophenoxy)picolinate

: 1020173-17-4
4-(2-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;