1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidine-2-thione

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Chemical Name:1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidine-2-thione
CAS No.:647839-18-7
Molecular Formula:C₃₂H₅₄N₂O₆SSi₂
Molecular Weight:651.028
Hs Code.:

1-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1<i>H</i>-pyrimidine-2-thione

Synonyms:1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidine-2-thione

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Chemical Property of 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidine-2-thione

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Technology Process of 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidine-2-thione

There total 5 articles about 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 647839-17-6
1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one

: 647839-18-7
1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidine-2-thione

Guidance literature:: With Lawessons reagent; In toluene; for 2h; Heating;
DOI:10.1021/jo035246b

Reference yield:

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 647839-18-7
1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidine-2-thione

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. Na₂CO₃; tetrabutylammonium bromide; 2,4,6-triisopropylbenzenesulfonyl chloride / CH₂Cl₂ / 20 °C

1.2: 89 percent / Et₃N; 1,4-diazabicyclo[2,2,2]octane / acetonitrile / 3 h / 20 °C

2.1: Lawesson's reagent / toluene / 2 h / Heating

With Lawessons reagent; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammomium bromide; sodium carbonate; In dichloromethane; toluene;
DOI:10.1021/jo035246b

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 647839-18-7
1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidine-2-thione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / imidazole / dimethylformamide / 12 h / 20 °C

2.1: aq. Na₂CO₃; tetrabutylammonium bromide; 2,4,6-triisopropylbenzenesulfonyl chloride / CH₂Cl₂ / 20 °C

2.2: 89 percent / Et₃N; 1,4-diazabicyclo[2,2,2]octane / acetonitrile / 3 h / 20 °C

3.1: Lawesson's reagent / toluene / 2 h / Heating

With Lawessons reagent; 1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammomium bromide; sodium carbonate; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo035246b