4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenylheptanoic acid ethyl ester

Base Information

Chemical Name:4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenylheptanoic acid ethyl ester
CAS No.:120019-24-1
Molecular Formula:C₂₁H₂₃F₂NO₅
Molecular Weight:407.414
Hs Code.:

Synonyms:4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenylheptanoic acid ethyl ester

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Chemical Property of 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenylheptanoic acid ethyl ester

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Technology Process of 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenylheptanoic acid ethyl ester

There total 2 articles about 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenylheptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 59830-60-3
benzyl (1S)-(1-formyl-2-phenylethyl)carbamate

: 120019-24-1
4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenylheptanoic acid ethyl ester

Guidance literature:: With zinc; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)82154-1

Reference yield:

: 114744-85-3
[(S)-1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

: 120019-24-1
4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenylheptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / lithium aluminium hydride / diethyl ether / 1 h / 0 °C

2: 61 percent / zinc / tetrahydrofuran / reflux; rt, 15 h

With lithium aluminium tetrahydride; zinc; In tetrahydrofuran; diethyl ether;
DOI:10.1016/0040-4020(95)00896-G