3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide

Base Information

Chemical Name:3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide
CAS No.:1363773-45-8
Molecular Formula:C₂₁H₂₃Cl₂N₅S
Molecular Weight:448.419
Hs Code.:

Synonyms:3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide

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Chemical Property of 3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide

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Technology Process of 3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide

There total 6 articles about 3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 39577-43-0
1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine

: 26028-65-9
5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

: 1363773-45-8
3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide

Guidance literature:: 5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione; With triethylamine; In ethanol; for 0.25h; Reflux;

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine; With tetra-(n-butyl)ammonium iodide; In ethanol; for 4h; Reflux;
DOI:10.2174/157018012799129882

Reference yield:

: 64310-32-3
1-(4-chlorobenzoyl)thiosemicarbazide

: 1363773-45-8
3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / Reflux

2.1: triethylamine / ethanol / 0.25 h / Reflux

2.2: 4 h / Reflux

With triethylamine; sodium hydroxide; In methanol; ethanol;
DOI:10.2174/157018012799129882

Reference yield:

: 1126-46-1
Methyl 4-chlorobenzoate

: 1363773-45-8
3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / methanol / Reflux

2.1: hydrogenchloride / methanol / 1 h / Reflux

3.1: sodium hydroxide / methanol / Reflux

4.1: triethylamine / ethanol / 0.25 h / Reflux

4.2: 4 h / Reflux

With hydrogenchloride; hydrazine hydrate; triethylamine; sodium hydroxide; In methanol; ethanol;
DOI:10.2174/157018012799129882