4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine

Base Information

Chemical Name:4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine
CAS No.:159706-36-2
Molecular Formula:C₂₆H₂₃F₆NO₂
Molecular Weight:495.465
Hs Code.:

Synonyms:4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine

Chemical Property:

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Technology Process of 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine

There total 4 articles about 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 159706-35-1
(S)-4-benzyl-3-phenylmorpholin-2-one

: 159707-06-9
3,5-bis-(trifluoromethyl)benzyl trifluoromethanesulfonate

: 159706-36-2
4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 - -50 ℃;
DOI:10.1021/jm950654w

Reference yield:

: trifluoromethane-sulfonate ester

: 3-(S)-Phenyl-4-benzyl-2-morpholinone

: 32707-89-4
3,5-bis(trifluoromethyl)benzenemethanol

: L-Selectride

: 159706-36-2
4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine

Guidance literature:: In tetrahydrofuran; ethyl acetate; toluene;

Reference yield:

: 32707-89-4
3,5-bis(trifluoromethyl)benzenemethanol

: 159706-36-2
4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-collidine / hexane / 1.5 h / 20 °C

2: 1.) L-Selectride / 1.) THF, -70 to 0 deg C, 2.) THF, 2h, -40 deg C

With 2,4,6-trimethyl-pyridine; L-Selectride; In hexane;
DOI:10.1016/S0957-4166(97)00058-X