C₁₇H₁₃ClN₂O

Base Information

• Chemical Name: C₁₇H₁₃ClN₂O
• CAS No.: 350479-68-4
• Molecular Formula: C₁₇H₁₃ClN₂O
• Molecular Weight: 296.756
• Mol file: 350479-68-4.mol

Synonyms:C₁₇H₁₃ClN₂O

Chemical Property of C₁₇H₁₃ClN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₃ClN₂O

There total 2 articles about C₁₇H₁₃ClN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + 1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one (13024-90-3) → C17H13ClN2O (350479-68-4)

Guidance literature:

With sodium acetate; acetic acid; at 20 ℃; for 1h;

DOI:10.1021/acs.orglett.6b03823

Reference yield:

N-4-chlorophenylhydrazine (1073-69-4) → C17H13ClN2O (350479-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 8 h / Reflux

2: acetic acid; sodium acetate / 1 h / 20 °C

With sodium acetate; acetic acid;

DOI:10.1021/acs.orglett.6b03823

Reference yield: 98.0%

2-methylidenetrimethylene carbonate (3775-32-4) + C17H13ClN2O (350479-68-4) → (5R,6R)-2-(4-chlorophenyl)-4-methyl-9-methylene-6-phenyl-7-oxa-2,3-diazaspiro[4.5]dec-3-en-1-one

Guidance literature:

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,3,5-trimethyl-benzene; at 20 ℃; for 20h; stereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.202002765

upstream raw materials:

benzaldehyde

1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one

N-4-chlorophenylhydrazine

Downstream raw materials:

1-(4-chlorophenyl)-4-((diphenylphosphoryl)(phenyl)methyl)-3-methyl-1H-pyrazol-5-ol

6-amino-1-(4-chlorophenyl)-3-methyl-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

6-amino-1-(4-chlorophenyl)-3-methyl-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile