(E)-N₂-methyl-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1,2-dicarboxamide

Base Information

• Chemical Name: (E)-N₂-methyl-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1,2-dicarboxamide
• CAS No.: 1259013-35-8
• Molecular Formula: C₁₉H₃₀N₄O₃
• Molecular Weight: 362.472

Synonyms:(E)-N₂-methyl-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1,2-dicarboxamide

Chemical Property of (E)-N₂-methyl-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1,2-dicarboxamide

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Technology Process of (E)-N₂-methyl-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1,2-dicarboxamide

There total 3 articles about (E)-N₂-methyl-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1,2-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

trimethylsilyl isocyanate (1118-02-1) + C2HF3O2*C18H29N3O2 (1259014-04-4) → (E)-N2-methyl-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1,2-dicarboxamide (1259013-35-8)

Guidance literature:

C₂HF₃O₂*C₁₈H₂₉N₃O₂; With potassium carbonate; at 20 ℃; for 0.333333h; Inert atmosphere;

trimethylsilyl isocyanate; at 20 ℃; for 18h;

With water; ammonium chloride; In water;

Reference yield:

(E)-3-(2,6,6-trimethylcyclohex-1-enyl)acrylic acid (14393-45-4) → (E)-N2-methyl-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1,2-dicarboxamide (1259013-35-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; acetonitrile / 18 h / 20 °C / Inert atmosphere

2.1: dichloromethane / 1 h / 20 °C

3.1: potassium carbonate / 0.33 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; acetonitrile;

Reference yield:

(E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate (1259014-02-2) → (E)-N2-methyl-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1,2-dicarboxamide (1259013-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 1 h / 20 °C

2.1: potassium carbonate / 0.33 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C

With potassium carbonate; In dichloromethane;

upstream raw materials:

trimethylsilyl isocyanate

C₂HF₃O₂*C₁₈H₂₉N₃O₂

(E)-3-(2,6,6-trimethylcyclohex-1-enyl)acrylic acid

(E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate

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