5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide

Base Information

Chemical Name:5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide
CAS No.:1572516-24-5
Molecular Formula:C₁₇H₁₂BrClF₆N₂O₃S
Molecular Weight:553.707
Hs Code.:

Synonyms:5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide

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Chemical Property of 5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide

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Technology Process of 5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide

There total 8 articles about 5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1573008-96-4
5-bromo-3-[(3-chloro-4,5-difluorophenyl)carbamoyl]-2-fluoro-4-methylbenzenesulfonyl chloride

: 779303-24-1
(2R)-1,1,1-trifluoro-2-propylamine

: 1572516-24-5
5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 20h; Inert atmosphere; Sealed tube;

Reference yield:

: 1427373-55-4
3-bromo-6-fluoro-2-methyl-benzoic acid

: 1572516-24-5
5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: chlorosulfonic acid / 5 h / 115 °C

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2.5 h / 20 °C

3: toluene / 0.75 h / Inert atmosphere; Reflux

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 80 °C / Inert atmosphere; Sealed tube

With chlorosulfonic acid; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; toluene; acetonitrile;

Reference yield:

: 90259-27-1
2-fluoro-6-methylbenzoic acid

: 1572516-24-5
5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; nitric acid / 15 °C

1.2: 4 h / 15 - 20 °C

2.1: chlorosulfonic acid / 5 h / 115 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2.5 h / 20 °C

4.1: toluene / 0.75 h / Inert atmosphere; Reflux

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 80 °C / Inert atmosphere; Sealed tube

With chlorosulfonic acid; oxalyl dichloride; nitric acid; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; toluene; acetonitrile;