prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate

Base Information

• Chemical Name: prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate
• CAS No.: 868046-17-7
• Molecular Formula: C₁₂H₁₀O₄
• Molecular Weight: 218.209
• Mol file: 868046-17-7.mol

Synonyms:prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate

Chemical Property of prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate

There total 8 articles about prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

prop-2-yn-1-yl (2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoate → prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate (868046-17-7)

Guidance literature:

With guanidine hydrochloride; triethylamine; In methanol; dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1111/cbdd.12874

Reference yield: 51.0%

caffeic acid (331-39-5,501-16-6) + propargyl bromide (106-96-7) → prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate (868046-17-7)

Guidance literature:

caffeic acid; With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium carbonate; for 0.5h;

propargyl bromide; With potassium iodide; at 20 ℃; for 48h;

DOI:10.1016/j.bmcl.2019.02.032

Reference yield: 31.0%

caffeic acid (331-39-5,501-16-6) + propargyl alcohol (107-19-7) → prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate (868046-17-7)

Guidance literature:

With dmap; In 1,2-dichloro-ethane; at 20 ℃; for 17h;

upstream raw materials:

3,4-dihydroxybenzaldehyde

isovanillin

(E)-3,4-di-O-acetylcaffeoyl chloride

caffeic acid