2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-1-(4-phenylpiperidin-1-yl)ethan-1-one

Base Information

Chemical Name:2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-1-(4-phenylpiperidin-1-yl)ethan-1-one
CAS No.:1451411-79-2
Molecular Formula:C₃₃H₄₀N₂O₅
Molecular Weight:544.691
Hs Code.:

Synonyms:2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-1-(4-phenylpiperidin-1-yl)ethan-1-one

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Chemical Property of 2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-1-(4-phenylpiperidin-1-yl)ethan-1-one

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Technology Process of 2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-1-(4-phenylpiperidin-1-yl)ethan-1-one

There total 3 articles about 2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-1-(4-phenylpiperidin-1-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 771-99-3
4-phenylpiperidine

: 361389-48-2
C₂₂H₂₇NO₆

: 1451411-79-2
2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-1-(4-phenylpiperidin-1-yl)ethan-1-one

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm400720h

Reference yield:

: 13074-31-2
Tetrahydropapaverine

: 1451411-79-2
2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-1-(4-phenylpiperidin-1-yl)ethan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: sodium hydroxide / ethanol; water / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With tetra-(n-butyl)ammonium iodide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400720h

Reference yield:

: 1451411-70-3
ethyl 2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}acetate

: 1451411-79-2
2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-1-(4-phenylpiperidin-1-yl)ethan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400720h