tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate
CAS No.:1428253-12-6
Molecular Formula:C₃₀H₃₇FN₈O₅S
Molecular Weight:640.739
Hs Code.:

tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

Synonyms:tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

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Chemical Property of tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

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Technology Process of tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

There total 8 articles about tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428253-11-5
tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-hydroxyethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1428253-12-6
tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

: 1226803-00-4
tert-butyl 4-(4-bromo-1-(2-hydroxyethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

: 1428253-12-6
tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

3: caesium carbonate / dimethyl sulfoxide / 100 °C

4: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

With hydrogenchloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;

Reference yield:

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 1428253-12-6
tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-((methylsulfonyl)oxy)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium hydroxide / methanol; water / 1 h / 20 °C

2.1: N-Bromosuccinimide / tetrahydrofuran / 0.25 h / -46 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 1.5 h

3.2: 4 h

3.3: 0.33 h / 20 °C

4.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

6.1: caesium carbonate / dimethyl sulfoxide / 100 °C

7.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

With hydrogenchloride; ammonium hydroxide; N-Bromosuccinimide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;